O-toluidine is an organic compound with a wide range of uses. The following are its main uses:
Dye industry: used to prepare azo dyes, triphenylmethane dyes, etc., and also as a dye intermediate, it plays an important role in the manufacture of various dyes such as red-based GBC and red-based G.
Pharmaceutical industry: used to prepare drugs such as o-cloxacillin, methaqualone, bisoprolol and rhodin.
Pesticide industry: used to synthesize pesticides such as chlordimeform.
Other uses: also used as a rubber vulcanization accelerator, paint drying agent, and synthetic saccharin, etc.
In summary, o-toluidine is widely used in dyes, medicines, pesticides and other chemical fields, and is an important organic synthesis raw material.
The preparation methods of o-toluidine mainly include the following:
Hydrogenation reduction method: o-nitrotoluene and hydrogen are added to the reactor, and a reduction reaction is carried out at a certain temperature and pressure to generate o-toluidine.
Iron powder reduction method: o-nitrotoluene is reduced with iron powder in a dilute acid medium, and then the crude o-toluidine is separated, and then the pure product is obtained through acid dissolution, alkali precipitation and other steps.
Direct amination method: o-nitrotoluene is directly reacted with ammonia under the action of a catalyst to generate o-toluidine, but the product purity is low.
These methods have their own characteristics and are suitable for different production needs. In practical applications, the appropriate preparation method can be selected according to the specific situation.
o-Toluidine Chemical Properties
Melting point -23 °C
Boiling point 199-200 °C(lit.)
density 1.008 g/mL at 25 °C(lit.)
vapor density 3.7 (vs air)
vapor pressure 0.26 mm Hg ( 25 °C)
refractive index n20/D 1.572(lit.)
Fp 185 °F
storage temp. 2-8°C
solubility 1.5 g/100 mL (25°C)
Colour Index 37077
form liquid
pka 4.44(at 25℃)
color light yellow to light amber
PH 7.4 (H2O, 20℃)Aqueous solution
Odor Aromatic, aniline-like.
explosive limit 1.5-7.5%(V)
Water Solubility 1.5 g/100 mL (25 ºC)
Sensitive Air & Light Sensitive
Merck 14,9536
BRN 741981
Contact Information
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Post time: Oct-12-2024